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Almost every form of health problems preceded by a form of lifestyle. These factors can be controlled or controlled and will be positive or negative impact on health. Lifestyle is one of the triggers various chronic diseases of modern and one of them is chronic kidney disease (CKD). The purpose of this study modules determine the effect of a healthy lifestyle to Interdialysis weight gain (IDWG) and the patient's quality of life, good health domains of physical, psychological, social relationships and environment. This research method is Quasi experimental by using one-group pretest-posttest design. A sample of 30 patients, the results of analysis using correlation and multiple linear regression showed that there was significant effect between the provision of a healthy lifestyle module to IDWG (-6,904> -2.4.495> 2.056) variable confounding (characteristics of respondents) influence on quality of life (p = 0.000).