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Hipertiroidism is a thyrotoxicosis caused by a hyperactive thyroid gland. Thyrotoxicosis is a clinical manifestation of excess thyroid hormone that circulates in the circulation. The prevalence ofhyperthyroidism in the Meureubo Community Health Center in 2016 was 36 cases, in 2017 there were 59 cases and in 2018 there were 86 cases. The purpose of this study was to determine the relationship of risk factors namely gender, stress level and exposure to cigarette smoke with the incidence of hyperthyroidism. Quantitative research methods with a case-control design. The number of samples in the study were 24 cases and 24 controls. The case in this study was all hyperthyroid sufferers and the controls study were at risk. The results of the study based on bivariate analysis with Chi-square test obtained gender (Pvalue = 0.019 and OR = 4.200), stress level (Pvalue = 0.001) and exposure to cicarette smoke (Pvalue = 0.006 and OR = 11.500). Conclusion there is a relationship between sex, stress level and exposure to cigarette smoke with the incidence of hyperthyroidism. Suggestion that you immediately consult a health center if you start experiencing symtoms, manage stress well, consume food with balanced nutrition exercise regularly and and to avoid exposure to cigarette smoke to reduce the risk of hyperthyroidism.