Scabies is a skin disease caused by the infestation and sensitization of Sarcoptes scabiei hominis variety, which is a parasitic tick that is able to dig tunnels in the skin and cause itching. The success of patients in preventing the transmission of scabies to others is largely determined by compliance and regularity in maintaining personal hygiene. Therefore, during treatment and care, a good level of behavior is needed from the sufferer. The purpose of this study was to determine the relationship between students' knowledge of scabies and scabies prevention efforts in Dayah Istiqamatuddin Babul Mu'arrif Serambi Aceh, XVI District, West Aceh Regency. This type of research is descriptive analytic with the research design used is a cross sectional study,with a total sample of 64 students taken using the stratified random sampling method . Data analysis includes univariate analysis by looking for the frequency distribution, and bivariate analysis using chi-square test with a significance value (α= 0.05). The results showed that the majority of respondents had knowledge in the less category as many as 26 people or about 40.6%, most of the respondents made efforts to prevent scabies in the less category, namely 23 people or 35.9%. From the results of the bivariate analysis, it is known that there is a relationship between the knowledge of students and efforts to prevent scabies with a p value of 0.000 (p <0.05). It is recommended to Health Officers at UPT Puskesmas Kaway XVI West Aceh Regency to further improve health promotion to students at Islamic boarding schools about the importance of scabies prevention efforts so that scabies prevention measures can be implemented properly.